Cultural Marxism features prominently in anti-semitic conspiracy theories advanced by white nationalists, neo-Nazis, and white supremacists. The basic premise is that racial or ethnic co-existence and acceptance of 'sexually deviant' behaviour is unnatural, growing acceptance of interracial relations, homosexual relations, and transgenderism is therefore seen as the product of external social engineering.

Cultural Marxism, from this perspective, is virtually synonymous with 'political correctness' (deemed to be its consequence) and promotes 'sexual bolshevism' (e.g. homosexuality) as well as racial co-existence as a means to weaken the white race by Jews and specifically 'Judeo-Bolsheviks' that have infiltrated political power in white countries. In other words, Cultural Marxism is an instrument to social engineer genocide.

The conspiracy theorists posit that communists, social-liberals, social-democrats, conservative liberals, and neoconservatives promote a cultural Marxist viewpoint.

This conspiracy theory features heavily into other conspiracy theories of Judeo-Bolshevism and 'Zionist Occupation Government'.